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According to NICE Technology Appraisal 875 (TA875), these criteria typically include a body mass index (BMI) of 35 kg/m or above, or 32.5 kg/m or above for people from South Asian, Chinese, other Asian, Middle Eastern, Black African or African-Caribbean family backgrounds, with at least one weight-related comorbidity

This imbalance is hypothesized to contribute to dysfunctions in the reward system, potentially manifesting as anhedonia and other depressive symptoms 45 , a clinical observation that aligns with the psychiatric side effects noted in GLP-1 RAs therapy

Impact of metabolic syndromeon neuroinflammation and the blood-brain barrier

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