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Note: Ozempic , Rybelsus , Mounjaro , Victoza , metformin, and Trulicity are not FDA-approved to treat obesity or for weight loss

In specific secondary analyses we examined the impact of antidepressant use, measured based on drug container inspection of medications used in the past month, classified according to the World Health Organization Anatomical Therapeutic Chemical classification: selective serotonin reuptake inhibitors (N06AB), tricyclic antidepressants (N06AA) and other less commonly prescribed medications (N06AX, N06AF, N06AG)

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It is important for providers to constantly screen and assess both motor and nonmotor symptoms to appropriately adjust therapies

Several trial design features explain the variation: the dose tested, how strictly participants followed co-interventions (diet and exercise), baseline metabolic health, duration of treatment, and individual differences in chromium handling