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With that regulatory brake reduced, IGF-1 LR3 interacts with IGF-1 receptors more directly and for a longer duration, which is why research protocols report a half-life of roughly 2030 hours, compared to native IGF-1s 1215 hours
While animal studies are promising, they do not guarantee equivalent effects or safety in humans
Beuther DA, Weiss ST, Sutherland ER
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