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The study found that the samples had markedly lower quality than the labels claimed and contained impurities like trace metals and residuals solvents

Supports Skin and Connective Tissue Renewal In human dermal fibroblast studies 7 , IGF-1 improved cellular proliferation and collagen remodeling, processes that underlie skin elasticity and repair

Cuthbertson DJ, Irwin A, Gardner CJ, Daousi C, Purewal T, Furlong N, et al

This was felt to be an erroneous finding related to the studys design

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This is vastly more dilute than topical formulations, but isolated cells in culture have direct peptide access without any barrier to penetration