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Collagen production*
Yes, semaglutide has one of the longest half-lives among GLP-1 medications
Nissen notes that SURMOUNT-MMOs use of all-cause mortality instead of cardiovascular death, consistent with this post hoc analysis, signals a shift for cardiovascular outcome trials
In adults with obesity and knee osteoarthritis, retatrutide delivered: 9mg dose: 26.4% body weight reduction at 68 weeks 12mg dose: 28.7% body weight reduction at 68 weeks (average of 71.2 pounds lost) Placebo: 2.1% body weight reduction The 68-week timeframe is longer than the Phase 2 trial, which partially explains the higher numbers
The rationale behind combining them is rooted in cellular metabolism
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