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The intranasal route is particularly relevant for CNS-targeted research with these compounds, as it facilitates delivery via the olfactory and trigeminal nerve pathways to the CNS, bypassing the blood-brain barrier

54 In another phase 2 trial done to evaluate the efficacy of orforglipron in adults with obesity without diabetes, it was found to lead to significant weight reduction compared to placebo

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Prog Neurobiol (2014) 118:118