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Footnotes 1
When compared with placebo or other therapies, GLP-1 agonists were associated with an increased risk of biliary disease [23]: Overall biliary disease: RR 1.37(95% CI 1.231.52) Cholelithiasis: RR 1.27 (95% CI 1.101.47) Cholecystitis: RR 1.36 (95% CI 1.141.62) Mechanisms: Reduced gallbladder motility Rapid weight loss increased cholesterol saturation and gallstone formation
However, some patients express concerns about compounded medication effectiveness
Generally people should be started on the lower dose and increased after 3 to 6 months
Contraindications and precautions depend on the exact product
Zerbo O, Losif AM, Walker C, Ozonoff S, Hansen RL, Hertz-Picciotto
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