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This mechanism was initially developed to manage blood sugar levels in people with type 2 diabetes, as GLP-1 also stimulates insulin secretion in response to glucose
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Further analysis of aged mice testes after FOXO4-DRI treatment revealed a reduction in interstitial SA--gal activity, along with decreased levels of senescence-associated proteins p53, p21, and p16
GLP-1 agonists have different safety constraints: absolute contraindication in personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2, and caution in patients with diabetic retinopathy or severe gastrointestinal disease
doi:10.1136/gut.20.1.37 165
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