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He and other researchers worked for more than a decade to duplicate the effects of exendin-4, mostly because early iterations of GLP-1s were quickly broken down by the human body
All experiments were conducted in compliance with the ARRIVE guidelines
Phase 3 figures point to a 23.7% mean weight loss at its highest dose over 68 weeks, with some trial participants experiencing as much as 28.7% reduction
Simultaneously, these agents suppress glucagon secretion, a hormone that raises blood sugar levels
Until more study is done on this combination in bigger, peer-reviewed clinical studies, it should be seen as experimental and only used under physician supervision and in ethical research settings
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