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BBR is suggested to upregulate the expression of LDL receptors in the human hepatoma cell line (HepG2) and to inhibit both cholesterol and TG synthesis in the liver, dose-dependently
However, in the other 12 CVOTs of SGLT2is, allocation to a SGLT2i was not significantly associated with lower limb amputations (RR, 1.06
External Application: Advantages of applying the drug externally to the skin
doi:10.1111/dom.14110 27
This means that removing a big amount of fat from the stomach area may be difficult and requires more than one session, which makes the idea of seeking other treatment options plausible
PLoS ONE 11(3):e0149912
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