Both iterations of Kozilek notably lack indestructible but make up for it with titanic stats
Phyrexia: All Will Be One gives us a nice mix of old and new, nostalgia and futurism, and also amps up the stakes in the Phyrexian story while continuing the games recent focus on artifacts
In an aggressive deck, this is likely to be more than enough to kill them off - and that's not accounting for any extra creatures you may have, any ramping you've done or spare mana you've created
How would Location cards impact the game
But in the end I managed to cast [scryfall]Miraris Wake[/scryfall] to double my mana (again) and after that it was just the matter of rounds before I beat them all dead
You can build around it with indestructible things, more spells than permanents, like swapping Phyrexian Arena for Sign in Blood and Eternal Witness for Regrowth and Sensei's Divining Top for Brainstorm